SUPER CARDARINE ( EXTREM FATBURNER )
In European preview on GW-0742. The brand new supplement based on Sarm GW-0742 developed by GlaxoSmithKline, a selective Peroxisome Proliferator Receptor Agonist (PPAR). Due to the completely independent mechanism of action from the hormonal axis, GW-0742 can be used in people of both sexes.
Super-GW is the new and powerful Sarm that differs from its predecessor, the Cardarina or GW-501516 for a greater synthesis and biological activity, up to 200 times more effective. Currently, it is the backbone of all clinical research on the PPARβ / δ agonist.
Appreciated in the latest tests for its rapid and extreme ability to reduce body fat while maintaining muscle mass. It provides evident results on resistance from the first dose, and is extremely versatile as it can be combined with other Sarms.
PPARβ / δ ligands are members of a group of nuclear receptors that play different roles in cell metabolism, development and differentiation. There are numerous effects on genes involved in metabolism, GW-0742 can help treat diabetic disorders, insulin sensitivity and fat burning in a dose-dependent manner. Skeletal muscle plays a significant role in insulin resistance and PPARβ / δ upregulates GLUT4, which regulates tissue glucose uptake. Administration of PPAR agonists increased HDL (good cholesterol) levels in vitro, resulting in an increase in reverse cholesterol transport. Studies suggest that PPARδ is a significant factor for lipid uptake in macrophages.
Super Cardarine GW-0742 improves fat loss by increasing glucose uptake in skeletal muscle tissue, modifying and improving energy metabolism. Turn fat into energy without lowering blood sugar levels. Originally developed to treat obesity and other metabolic diseases, it is gaining immense popularity due to its ability to burn fat rapidly even more effectively than its predecessor, the classic Cardarina.
Super Cardarine GW-0742 is also used profitably in the process of building muscle tissue. The mechanism of action is based on the stimulation of the expression of the anti-inflammatory cytokines IL-10 and TGF-β mRNA. Research shows that it greatly affects the process of increasing the rate of myogenesis and in the case of muscle damage, complete regeneration occurs twice as fast.
Super Cardarine GW-0742 enhances the oxidation of fatty acids by increasing the mitochondrial density in cells. The compound perfectly uses the fat of the cells, as well as the fats of the daily diet, using it as the primary fuel. The use of GW-0742 increases the number of mitochondria in the muscle tissue, which results in an increase in muscle efficiency. The high concentration of mitochondria allows to increase the efficiency of metabolic processes, allowing to generate more ATP. Finally, it increases the muscle contraction force and prolongs the maximum time of aerobic work.
Studies show that Super Cardarine GW-0742 alleviates changes in astrocytes (glial cells crucial in the remembering process), providing protection against neurodegenerative diseases.
Super Cardarine GW-0742 also enhances the chondrogenesis process, helping to protect the joints from degeneration. It has a beneficial effect on the condition of cartilage and joints, favoring the synthesis of type II collagen and glycosaminoglycan, components of cartilage in humans. §
Furthermore, the integration with GW-0742 influences, as mentioned, a greater secretion of the transforming growth factor beta (TGF-β), influencing optimal conditions of the joints. The TGF-β factor reduces the level of ossification, reduces inflammation and increases the stability of cartilages.